Imprimir Ver referencias Citación Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Lau K, Chan A. Lau K, & Chan A Lau, Kathleen, and Alex Chan. Impact and prognosis of the expression of IFN-α among tuberculosis patients #TA. 2 Minute Medicine, 22 julio 2020. McGraw-Hill, 2020. AccessMedicina. https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=551546§ionid=248705040APA Citation Lau K, Chan A. Lau K, & Chan A Lau, Kathleen, and Alex Chan. (2020). Impact and prognosis of the expression of ifn-α among tuberculosis patients #ta. (2020). 2 minute medicine. McGraw-Hill. https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=551546§ionid=248705040.MLA Citation Lau K, Chan A. Lau K, & Chan A Lau, Kathleen, and Alex Chan. "Impact and prognosis of the expression of IFN-α among tuberculosis patients #TA." 2 Minute Medicine McGraw-Hill, 2020, https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=551546§ionid=248705040. Descargar archivo de la citación: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Capítulo completo Sólo figuras Sólo cuadros Solo Videos Supplementary Content Arriba Impact and prognosis of the expression of IFN-α among tuberculosis patients #TA by Kathleen Lau, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Expression of IFN-α is found to be lower after successful treatment of tuberculosis. +Evidence Rating Level: 2 (Good) +Tuberculosis (TB) is an infectious disease killing over 1 million people annually worldwide, caused by the bacterium M. tuberculosis (M.tb). The immune response to TB involves T cells that express signalling proteins known as interferons (IFNs). IFN-γ, a Type II interferon, is known to combat bacterial infections. But Type I IFNs (α and β) can both bolster and hinder the mechanisms that protect against infection. Although the immune response leads to many TB infections becoming dormant, 10% of these cases develop clinical TB later on. Past studies have shown that the increase in Type I IFNs precedes clinical TB onset. This study investigated the Type I IFN levels in Indian TB patients. The blood samples of patients with active TB were analyzed before treatment, and 29% of these patients provided samples following successful treatment. Samples from the patients’ healthy household contacts (HHCs) were also analyzed. Prior to treatment, IFN-β and γ levels were comparable between TB patients and their HHCs (median fold expression for IFN-β: TB = 0.030, HHC = 0.031; for IFN-γ: TB = 0.071, HHC = 0.79). Contrastingly, IFN-α expression was 3.5 folds higher (p<0.0001) at 0.8 median fold in TB patients and 0.23 median fold in HHCs. As well, IFN-α was reduced by 3 folds in successfully treated patients, from a median fold expression of 0.37 to 0.13 (p<0.001), and IFN-β was reduced 2 folds, from 0.04 to 0.02 (p<0.001). IFN-γ was unchanged. Overall, IFN-α can be an important prognostic marker for TB, since its levels decrease dramatically after successful TB treatment. +Click to read the study in PlosONE +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.