Imprimir Ver referencias Citación Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. Serum IL-6 and TNF-α levels identified as independent predictors of COVID-19 severity and mortality. 2 Minute Medicine, 4 septiembre 2020. McGraw-Hill, 2020. AccessMedicina. https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=552928§ionid=249579608APA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. (2020). Serum il-6 and tnf-α levels identified as independent predictors of covid-19 severity and mortality. (2020). 2 minute medicine. McGraw-Hill. https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=552928§ionid=249579608.MLA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. "Serum IL-6 and TNF-α levels identified as independent predictors of COVID-19 severity and mortality." 2 Minute Medicine McGraw-Hill, 2020, https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=552928§ionid=249579608. Descargar archivo de la citación: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Capítulo completo Sólo figuras Sólo cuadros Solo Videos Supplementary Content Arriba Serum IL-6 and TNF-α levels identified as independent predictors of COVID-19 severity and mortality by Jack Lennon, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. Serum IL-6 and TNF-α were strong, independent predictors of disease severity and death among those with suspected and confirmed SARS-CoV-2 infection. +Evidence Rating Level: 2 (Good) +Hyperinflammatory responses, or cytokine storms, are known results of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), serving as a basis for disease severity and mortality. This cohort study from Mount Sinai Health System in New York aimed to investigate predictive biomarkers of pathogenic inflammation to better understand implicated immune pathways. Participants included 1,484 patients with either suspected (median [IQR] age = 60 [49-73], 53.9% male) or confirmed (median [IQR] age = 63 [53-72], 60.1% male) SARS-CoV-2 infection, for whom health and laboratory information was extracted from medical records. Four inflammatory cytokines known to contribute to pathogenic inflammation were measured: CAR T cell-associated CRS-IL-6, IL-8, TNF-α, and IL-1β, subsequently assessing their relationships to severity and survival. A total of 1,953 specimens were analyzed, mostly upon hospital admission (median [IQR] time = 1.2 days [0.7 to 3.0] days) using the ELLA rapid detection enzyme-linked immunosorbent assay (ELISA) microfluids platform. This study found that high serum TNF-α, IL-6 and IL-8 were strong, independent predictors of patient survival (p = 0.0140, p < 0.0001, p = 0.0205, respectively). When controlling for disease severity, hypoxia and other vitals, common lab inflammation markers, comorbidities and demographics, TNF-α and IL-6 serum levels continued to be strong predictors of mortality. Overall, this study suggests that serum levels of IL-6 and TNF-α should be considered among patients with suspected or confirmed SARS-CoV-2, which may better inform treatment and disease course. +Click to read the study in Nature +©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.