Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission.

1. In this cross-sectional study of Japanese patients with cancer and health care workers, the seroprevalence of SARS-CoV-2 antibodies did not differ between the two cohorts.

2. However, results suggest that comorbid cancer and treatment with systemic therapy, including chemotherapy and immune checkpoint inhibitors, may be associated with differences in serum SARS-CoV-2 antibody levels.

Evidence Rating Level: 2 (Good)

Study Rundown:

Patients with cancer and health care workers (HCWs) are both demographic groups at high risk of SARS-CoV-2 infection. Assessing the antibody status of patients with cancer and HCWs can aid in understanding the spread of COVID-19 in cancer care as well as the extent of disease and overall prognosis among various patient cohorts. This cross-sectional study aimed to evaluate serum SARS-CoV-2 antibody status in patients with cancer and HCWs during the COVID-19 pandemic in Japan, focusing on data from two comprehensive cancer centers in the epidemic area surrounding Tokyo between August and October 2020. The primary outcome and measure of the study was seroprevalence and antibody levels, where seropositivity was defined as positivity to nucleocapsid IgG (N-IgG) and/or spike IgG (S-IgG). Serum levels of SARS-CoV-2 IgM and IgG antibodies against the nucleocapsid and spike proteins were measured via chemiluminescent enzyme immunoassay. Among 500 patients with cancer and 1,190 HCWs enrolled in the study, the seroprevalence was 1.0% and 0.67% respectively. However, the levels of IgG antibodies against nucleocapsid and spike protein were significantly lower in patients with cancer when compared to HCWs (N-IgG: β, −0.38 and S-IgG: β, −0.39). Furthermore, N-IgG levels were significantly lower in cancer patients who received chemotherapy compared to those who did not while both N-IgG and S-IgG levels were significantly elevated in patients who received immune checkpoint inhibitors (ICI) than in those who did not. These findings indicate that seroprevalence was not different in patients with cancer compared with HCWs, in contrast to the immune response to SARS-CoV-2, which may differ between the two cohorts. Further studies are needed to determine the influence of comorbid cancer and cancer treatments on the immune response to SARS-CoV-2. A limitation of this study was the potential sampling bias in the patient population as it included various cancer types, ages, and stages from only one hospital institution.

In-Depth [cross-sectional study]:

This prospective cross-sectional study took place between August 3 and October 30, 2020, enrolling participants from two comprehensive cancer centers in the epidemic area around Tokyo, Japan. Inclusion criteria included patients with cancer aged 16 years or older and employees from the National Cancer Center (NCC) Hospital and its East campus while participants with suspected COVID-19 infection at the time of enrollment were excluded. To further specify, cancer of any type and cancer treatments, including chemotherapy, surgery, immune checkpoint inhibitors, radiotherapy, and targeted molecular therapy were analyzed individually for SARS-CoV-2 antibody status. In total, 500 patients with cancer (median age, 62.5 years [21-88 years]; 265 men [55.4%]) and 1,190 HCWs (median age, 40 years [20-70 years]; 382 men [25.4%]) were enrolled in the study. Among patients with cancer, 489 (97.8%) had solid tumors, and 355 (71.0%) had received anticancer treatment within 1 month of diagnosis. The cohort of HCWs included 385 (32.3%) nurses or assistant nurses, 266 (22.4%) administrative staff, 197 (16.6%) research staff, 179 (15.0%) physicians, 113 (9.5%) technicians, and 50 (4.2%) pharmacists. Upon analysis, the seroprevalence was 1.0% (95%CI, 0.33%-2.32%) in cancer patients and 0.67% (95%CI, 0.29%-1.32%) in HCWs (P = .48), posing only minute statistical differences. However, the N-IgG and S-IgG serum antibody levels were significantly lower in cancer patients than in HCWs (N-IgG: β, −0.38; 95%CI, −0.55 to −0.21; P < .001; and S-IgG: β, −0.39; 95%CI, −0.54 to −0.23; P < .001). Furthermore, among patients with cancer, N-IgG levels were significantly lower in those who received chemotherapy than in those who did not (median N-IgG levels, 0.1 [IQR, 0-0.3] vs 0.1 [IQR, 0-0.4], P = .04) while both N-IgG and S-IgG levels were significantly elevated in patients receiving ICI (median N-IgG levels: 0.2 [IQR, 0.1-0.5] vs 0.1 [IQR, 0-0.3], P = .02; S-IgG levels: 0.15 [IQR, 0-0.3] vs 0.1[IQR, 0-0.2], P = .02).

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