Imprimir Ver referencias Citación Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. AMA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. 2 Minute Medicine, 7 julio 2021. McGraw Hill, 2021. AccessMedicina. https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=568328§ionid=257480419APA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. (2021). Plasma il-12/ifn-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. (2021). 2 minute medicine. McGraw Hill. https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=568328§ionid=257480419.MLA Citation Lennon J, Chan A. Lennon J, & Chan A Lennon, Jack, and Alex Chan. "Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults." 2 Minute Medicine McGraw Hill, 2021, https://accessmedicina.mhmedical.com/updatesContent.aspx?gbosid=568328§ionid=257480419. Descargar archivo de la citación: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley © Copyright Clip Capítulo completo Sólo figuras Sólo cuadros Solo Videos Supplementary Content Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults by Jack Lennon, Alex Chan Listen +Originally published by 2 Minute Medicine® (view original article). Reused on AccessMedicine with permission. +1. In the context of elevated amyloid-beta, IL-12p70 was associated with slower cognitive decline. +2. IFN-γ was associated with slower cognitive decline irrespective of amyloid-beta deposition. +Evidence Rating Level: 2 (Good) +It is currently understood that immune dysregulation, as well as premature immunosenescence and cytokine levels, impact the neurodegenerative process. Less understood, however, is the predictive value of cytokine levels in the context of cognitive trajectories in cognitively unimpaired individuals. This is particularly important among those who are amyloid-beta- (Aβ) positive. This longitudinal study assessed baseline plasma for nine cytokines of 298 cognitively unimpaired older adults (50 to 90 years old) to determine whether or not these biomarkers were associated with cognitive decline and Aβ deposition. Cytokine levels were also compared to Aβ and tau PET as well as neurodegeneration. Eligible participants had a score of 27 or greater on the age- and education-adjusted Mini Mental Status Examination and scored with the normatively average range on several other neuropsychological measures. Those with unstable medical or psychiatric conditions, as well as those with a stroke history, were excluded. Elevated IL-12p70 was found to be associated with slower cognitive decline in the context of increased Aβ (false discovery rate [FDR] = 0.0023). Conversely, IFN-γ was associated with cognitive decline irrespective of Aβ findings (FDR = 0.013). Elevated IL-12p70 was also associated with reduced neurodegeneration and tau protein in those with elevated Aβ. Overall, this study demonstrates the role of immune dysregulation in neurodegeneration, such that certain cytokines may serve a protective role in slowing cognitive decline in those with and without elevated Aβ. +Click to read the study in Alzheimer’s and Dementia +©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.